Prosjekt vi støtter

GPR44 as a PET marker for measuring beta cell mass in human.

Pathophysiologycaemia risk in insulin-treated diabetes patients:more than the sum of the parts? Typ 1 diabetes.

Rap and Ras signalling in insulin secretion.

Succinate-induced glucose uptake in skeletal muscle - a new therapeutic target for diabetes?

CD36 as a therapeutic target to improve beta cell function in type 2 diabetes

Characerization of the diabetic pancreas to unravel the pathogenesis and etiology of type 1 diabetes

Diabetes associated vascular complications caused by impaired efferocytosis, inflammatory resolution and fibrotic tissue repair

Discovery and functional validation of regulatory networks in human pancreatic islets to identify targetable disease mechanisms underlying Type 2 diabetes

How many diseases are type 2 diabetes? Confirmation, evaluation and implementation of a new diabetes subclassification

Mechanisms in skin wound healing in non-diabetic and diabetic conditions and the effect of wound treatment with chemokines

Novel therapeutic tools and new biomarkers in diabetes with focus on islet specifik microRNAs

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts

Role of acetyltransferase GCN5 in endothelial oxidative stress in diabetes

Translational studies of insulinsecreting cells derived from induced pluripotent stem cells

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

6000 steps for better health – a randomised 12-month intervention study

Autophagy in control of beta-cell mass and function in Type 2 Diabetes

Communication between virus-infected pancreatic beta-cells and the immune system: implication for Type 1 diabetes

Contribution of genes and non-coding RNAs expressed by Kupffer cells in insulin resistance

Determining the microbiota in subjects with prediabetes

Does Glycation of apoA-I links to higher risk of cardiovascular complications in diabetic patients?

In collaboration with Prof. PO Berggren, Karolinska Institutet: Evaluating vision in the baboon following pancreatic islet transplantation in the eye anterior chamber

Genetic and transcriptomic studies of fetal pancreas to understand fetal programming and development and identification of blood based biomarkers for pancreatic development

Growth differentiation factor 11 (GDF11) – a fons adolescentia for the pancreatic beta-cell that can delay or prevent onset of type 2 diabetes?

Molecular control over a neuronal circuit that mediates feeding behaviour – and important new target in the fight against diabetes

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts

Short chain fatty acids; gut metabolites with implications for metabolic health

The importance of endothelial and red blood cell dysfunction for vascular complications in type 2 diabetes

The role of the duodenal microbiota in the etiopathology of Type 1 Diabetes

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

An in vivo approach to understand inositide signalling in the pancreatic beta cell

Betydelsen av budbärarämnet cAMP för reglering av insulin- och glukagonfrisättningen

Cellular interactions of mesenchymal stromal cells in type 1 diabetes

Correlation between systemic insulin resistance and bimodal adipose cell response

En ny unik medicinsk behandling av typ-2 diabetes baserat på hämmandet av proteinkinaset STK25

Hur påverkar fetma och typ 2 diabetes muskelstamcellernas funktion?

Novel strategies for treating diabetes

The role of pancreatic macrophages for development and maturation of islets of Langerhans and long-term metabolic control

Tissue factor signaling in islets and beta-cells

Träningsintervention vid metabola sjukdomar

Typ 2 diabetes: en betacellsdegenerativ sjukdom?

Understanding redox signalling in diabetic cardiomyopathy: role of AP-1 transcription factor JunD

Vilken påverkan har ärftlighet på muskelegenskaper och metabolsjukdom? - funktionen av RAB3GAP2 och MAOA

Assembly of the insulin granule secretory machinery

Can high concentrations of IAPP in plasma indicate the formation of beta-cell toxic species?

Dissecting the role of mitochondrial dysfunction in pancreatic beta-cells in Type 2 Diabetes

Does brusatol counteract high-fat diet-induced glucose intolerance in mice?

Expansion of pancreatic islets in vitro and transplantation treatment in diabetic mice

Gastric bypass surgery as a model for identification of new treatments for Type 2 Diabetes

Mechanisms underlying 'browning' of white adipose tissue

Myeloid-derived suppressor cells for tolerance to islet transplants

Neural control of the endocrine pancreas - from molecular pathways to human physiology in health and disease

Novel approaches for monitoring of endogenous ?-cells

Quantitate imaging as a tool to characterize the ongoing pathophysiology in children with recent onset type 1 diabetes

Targeted exercise intervention in the prevention of metabolic disease

The gamma-4 subunit of voltage-gated calcium ion channels (CaV?4) is an effector of beta-cell dedifferentiation in type 2 diabetes and a potential target for disease-modifying treatment

The role of arginase as a novel therapeutic target to improve cardiovascular function in type 2 diabetes

Transplantation of human islets in oxygenated macrocapsules to patients with type 1 diabetes mellitus

A systematic exploration of proteins for future site-targeted delivery of therapeutics to the native human islets

Characterisation of VEGF-B as a regulator of pancreatic B-cell lipid handing and function

Farnesoid X receptor isoforms and their roles in liver energy metabolism

Insulin suppresses counterregulatory glucagon secretion by an indirect effect mediated by stimulation of somatostatin secretion from delta cells

Interstitial GABA regulates alpha, beta and delta cells in human islets

Mechanisms for and consequences of ectopic lipid accumulation

Molecular mechanisms and treatment strategies of T2DM

Normalizing risk of death and cardiovascular diseases in type 1 diabetes

Rediscovery of the etiology of T1D in humans

Study of the neuroimmune synapse in the islet of Langerhans

Funding of this grant will help Spring Point Project achieve its mission to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

A novel approach for non-invasive monitoring of endogenous beta-cells

Characterization of proteins and drugs that effect insulin granule docking

Drug Repositioning to Prevent Activity-Dependent Calcium Signals in Pancreatic Beta-cells and Type-2 Diabetes Progression

GIP and ostepontin in islet cell function- can GIPR variants influence response to treatment in type-2 diabetes?

In vivo imaging of functional pancreatic beta-cell mass

Islet metabolism and circadian rhythm

Local bioengineering of muscle prior to islet transplantation to improve engraftment and induce immunological shielding

Means to preserve and restore beta-cell mass in type 1 diabetes mellitus

Mechanistic studies of a novel mucosal tolerance-inducing molecule that type-1 diabetes

Molecular mechanisms and treatment strategies of T2DM

Biomarkers for functional pancreatic beta-cell mass

Clinical and experimental studies of insulin resistance

Genetics of Insulin sensivity: An integrated approach to discovery

Islet metabolism circadian rhythm melatonin receptors and clock genes

Molcular mechanism and treatment strategies of Type-2 diabetes

Myeloid-derived suppressor cells for tolerance to islet transplants

Ongoing pathogenic processes in the pancreas at onset or prior to onset of Type 1 Diabetes in humans

Regulation of skeletal muscle insulin resistance

Stem cell therapies to regenerate the endocrine pancreas in type 1 diabetes mellitus

Transcription factors regulating insulin sensivity in human adipose tissue

Translating genetic associations for Type-2 diabetes to biological processes using chromatin maps

Analysis of tethering factors in the regulation of Glut4 spatial dynamics

Are human SPARC isoforms suitable peripheral makers of insulin resistance and diabetes-related complications?

GLP-1R activation for the treatment of stroke in diabetes

Hybrid preservation fluids and modular enzyme systems: significant means to optimizehuman islet transplantation

Investigation of the association between glucokinase and the pro-apoptotic protein BAD in pancreatic beta-cells

Investigation of the incretin pathway in Maturity onset diabetes of the young (MODY) secondary to heterozygous hepatocyte nuclear factor 1 alpha (HNF1A) gene mutations

Mesenchymal Stem Cells for Treatment of Newly Onset Type 1 Diabetes

Peripheral neuropathy and muscle weakness: how do they influence the safety of daily gait tasks for people with diabetes?

Protein phosphate 5 can protect pancreatic beta-cells against the diabetogenic propeties of glucocorticoids and a high-fat diet

Role of adipose tissue in age-dependent beneficial effects of PI 3-kinase pathway inactivation on glucose and lipid homeostasis

The regulation of metalloproteinases and tissue inhibitors of metalloproteinases in adipose inflammation and type2diabetes

Funding of this grant request will help Spring Point Project achieve its mission to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes

Exendin-4 protection of normal and diabetic human coronary artery endothelial cells in diabetic macroangiopathy

Extracellular nucleotide receptors as targets for the treatment of diabetes

Funding of Islet Transplant Administrator within the DRWF Islet Isolation Facility

Hybrid preservation fluids and modular enzyme systems: significant means to optimize human islet transplantation

Development of a protocol using LMW-DS and Compstatin to inhibit the IBMIR in xenogeneic islet transplantation

Exendin-4 protection of normal and diabetic human coronary artery endothelial cells in diabetic macroangiopathy

Extracellular nucleotide receptors as targets for the treatment of diabetes