Prosjekt vi støtter

Precision medicine for increased physical fitness and muscle health in the treatment of diabetes.

Discovery of islet-resident catecholamine-producing B cells as promising potent regulatory Immune cells in type 1 diabetes.

Using genomic analysis to elucidate disease mechanisms for type 2 diabetes and its comorbidities.

Early social marginalization in young and middle-aged individuals with type 1 and type 2 diabetes: Excess risk and machine learning based prediction.

Transcriptomic landscape of skeletal muscle in polycystic ovary syndrome.

Linking T cell behaviour and gene expression profiles to determine tolerance mechanisms to halt progression of type 1 diabetes.

Increased and cell surface miss-targetting of mitochondrial VDAC1 causes mtDNA leakage leading to autoimmune response and causing beta-cell demise in type 1 diabetes.

Breastfeeding and risk of childhood type 1 diabetes: mechanisms and effect modifiers.

Impact of gestational diabetes mellitus on child gut microbiota and neurocognitive development.

Genome Editing in Human Stem Cell-Derived Islets: A Novel Strategy for Treating Monogenic Diabetes.

In-depth analysis of immune response to identify changes associated with progression and endotypes of type 1 diabetes.

Importance of a novel miRNA in the development and early prediction of type 1 diabetes.

Unraveling the genetic and epigenetic landscape of advanced glycation end products: a potential link to cardiovascular disease in adults with type 1 diabetes.

Engineered enveloped particles for genome editing of stem cell derived pancreatic islets in vitro.

Beta-cell cytoskeletal keratin 18 and its type 1 diabetes associated variant (SNP) in beta-cell function and stress protection.

Accelerated diabetic wound healing by a wound homing peptide.

Efficacy of antiviral therapy: aiming at type 1 diabetes.

Paracrine control of islet hormone exocytosis in diabetes.

Novel selectively targeted stimulation of the β2-adrenoceptor for the treatment of type 2 diabetes.

Can we prevent adipocyte dysfunction and metabolic disease via metabolic targeting of the adipose tissue?

Roles of splice isoform CD59-IRIS-1 in beta-cell identity and function.

Stimulating β-cell regeneration as a novel treatment of diabetes.

Collagenous Peptides in the Regulation of Adipose Tissue Remodelling.

A randomized double-blind clinical trial comparing Hypochlorous Acid and Polyhexamethylene biguanide in treating diabetic foot ulcers.

High resolution optical 3D imaging to understand human diabetes pathophysiology in a whole organ context.

Studies of T2D disease mechanisms in human islets.

The role of immune cell-microbial interactions for long-term islet function and glucose homeostasis.

Treat and prevent type 1 diabetes by mesenchymal stromal cells.

Gastrointestinal adverse effects of metformin in treatment of type 2 diabetes - patients’ perspective and microbiota.

Regulation of glucose homeostasis in type 2 diabetes by eicosanoids.

The role of amp-activated protein kinase in the regulation of fatty acid synthesis in adipocytes.

The inner ear as a target for insulin action-implications for diabetes complications.

Pathophysiologycaemia risk in insulin-treated diabetes patients:more than the sum of the parts? Typ 1 diabetes.

Succinate-induced glucose uptake in skeletal muscle - a new therapeutic target for diabetes?

Rap and Ras signalling in insulin secretion.

GPR44 as a PET marker for measuring beta cell mass in human.

GPR44 as a PET marker for measuring beta cell mass in human

Rap and Ras signalling in insulin secretion

Improvement of diabetic beta cell functions using remotely controlled magnetic nanoparticles.

Neonatal infections alter islet maturation and long-term glucose homeostasis.

The importance of red blood cell dysfunction for cardiovascular complications in diabetes.

Reducing sedentary time to improve glucose and lipid metabolism.

The first absolute account of the islet mass distribution in the pancreas of healthy and diabetic individuals.

Arginase-2: The potential role of arginine metabolism in beta cell dysfunction.

Examining acinar tissue of type 1 diabetes pancreata to elucidate the etiology of the disease.

Functional validation of T2D dysregulated beta-cell gene regulatory networks.

Role and relevance of RNA editing of immune cells in obese-induced type 2 diabetes.

Tissue-targeted circadian interventions for identifying genetic and molecular mechanisms regulating metabolic integrity in healthy and type 2 diabetic humans.

Delineating novel mechanisms of human adipocyte lipid metabolism in typs 2 diabetes and insulin resistance;miR-221-3p as a bait

Enhancer landscape remodelling during macrophage metaflammatory activation and its involvement in obesity induced metabolic disorder.

Induced endothelial expression of podocyte specific Retinoic acid receptor responder1 (Rarres1) in Diabetic Kidney Disease (DKD) accelerates renal injury.

Subcutaneous adipogenesis is a marker of future risk of Type 2 Diabetes – role of endothelial and precursor cell senescence.

The novel MafA target gene PPP1R1A is modulating the GLP1R-amplifying glucose-stimulated insulin secretion.

Why do type-2 diabetic patients express less synaptotagmin 13 (SYT13) in their islets of Langerhans than healthy individuals?

Discovery and functional validation of regulatory networks in human pancreatic islets to identify targetable disease mechanisms underlying Type 2 diabetes.

Novel therapeutic tools and new biomarkers in diabetes with focus on islet specifik microRNAs.

Translational studies of insulinsecreting cells derived from induced pluripotent stem cells.

How many diseases are type 2 diabetes? Confirmation, evaluation and implementation of a new diabetes subclassification.

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts.

CD36 as a therapeutic target to improve beta cell function in type 2 diabetes.

Characerization of the diabetic pancreas to unravel the pathogenesis and etiology of type 1 diabetes.

Diabetes associated vascular complications caused by impaired efferocytosis, inflammatory resolution and fibrotic tissue repair.

Mechanisms in skin wound healing in non-diabetic and diabetic conditions and the effect of wound treatment with chemokines.

Role of acetyltransferase GCN5 in endothelial oxidative stress in diabetes.

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes.

Determining the microbiota in subjects with prediabetes.

Molecular control over a neuronal circuit that mediates feeding behaviour – and important new target in the fight against diabetes.

Growth differentiation factor 11 (GDF11) – a fons adolescentia for the pancreatic beta-cell that can delay or prevent onset of type 2 diabetes?

The role of the duodenal microbiota in the etiopathology of Type 1 Diabetes.

6000 steps for better health – a randomised 12-month intervention study.

The importance of endothelial and red blood cell dysfunction for vascular complications in type 2 diabetes.

In collaboration with Prof. PO Berggren, Karolinska Institutet: Evaluating vision in the baboon following pancreatic islet transplantation in the eye anterior chamber.

Refining Immunosuppression to Prevent Rejection of Porcine Islet Xenografts.

Short chain fatty acids; gut metabolites with implications for metabolic health.

Autophagy in control of beta-cell mass and function in Type 2 Diabetes.

Communication between virus-infected pancreatic beta-cells and the immune system: implication for Type 1 diabetes.

Contribution of genes and non-coding RNAs expressed by Kupffer cells in insulin resistance.

Does Glycation of apoA-I links to higher risk of cardiovascular complications in diabetic patients?

Genetic and transcriptomic studies of fetal pancreas to understand fetal programming and development and identification of blood based biomarkers for pancreatic development.

Spring Point Project, its mission is to provide an unlimited source of pig islet cells to accelerate the availability and affordability of islet transplantation to cure diabetes.

Diabetogenic effects of statins

Importance of cell-cell interactions and heterogeneity in human pluripotent stem cell-derived islet-like clusters to model diabetes

Novel treatments for type 2 diabetes via SIRT1 activation and regulation of insulin sensitivity in muscle and adipose tissues

The association between self-management of type 1 diabetes and diabetic complications – Finnish Diabetic Nephropathy (FinnDiane) Study

Transcription factor Prox1 – a potent regulator of glucose metabolism?

Vascular homing peptide CAR in pathological retinal angiogenesis and CAR-decorin in ocular fibrosis in mouse

An in vivo approach to understand inositide signalling in the pancreatic beta cell.

Betydelsen av budbärarämnet cAMP för reglering av insulin- och glukagonfrisättningen.

Cellular interactions of mesenchymal stromal cells in type 1 diabetes.

Correlation between systemic insulin resistance and bimodal adipose cell response.

En ny unik medisinsk behandling av type 2-diabetes basert på hemming av proteinkinaset STK25.

Hvordan påvirker fedme og diabetes type 2 funksjonen til stamcellene i musklene?

Novel strategies for treating diabetes.

The role of pancreatic macrophages for development and maturation of islets of Langerhans and long-term metabolic control.

Tissue factor signaling in islets and beta-cells.

Träningsintervention vid metabola sjukdomar.

Typ 2 diabetes: en betacellsdegenerativ sjukdom?

Understanding redox signalling in diabetic cardiomyopathy: role of AP-1 transcription factor JunD.

Vilken påverkan har ärftlighet på muskelegenskaper och metabolsjukdom? - funktionen av RAB3GAP2 och MAOA.

Enhanced wound healing in diabetes by wound homing, cell penetrating peptide induced syndecan-4 dependent cell migration

Identification of small molecules that enhance beta cell proliferation and differentiation

In vitro maturation of stem cell derived pancreatic beta cells for diabetes research grant

Significance of HDL-C on energy metabolism in type 2 diabetes

Transcriptional control of dietary sugar metabolism and homeostasis